It is inexpensive and easy to perform, with high sensitivity and specificity. Since then it has been the most widely used test for diagnosis of CTD. IF-ANA was designed by George Friou in 1957.
IF-ANA: The standard ANA testing techniqueīefore development of IF-ANA test, LE cell preparation was the only method used for diagnosis of SLE. This article also gives an overview on advancement in various ANA detection methods, their future prospects along with advantages, disadvantages and guidelines for use of these tests. In this review we have discussed in brief how ANA were discovered and found to be associated with CTD. Various detection methods are in use and there is continuous pouring of newer techniques to facilitate diagnosis and therapeutic monitoring in CTD patients. Their detection with high sensitivity and specificity is therefore of utmost importance. Not only are these antibodies involved in the disease pathogenesis, but they also constitute the basis for diagnosis and treatment of CTD. Although lower amounts of these antibodies can be seen in the normal population as well, a spurt in titers is seen in patients of CTD. ANA are a specific class of autoantibodies that have the capability of binding and destroying certain structures within the nucleus of the cells. Connective tissue diseases (CTD) are a group of autoimmune disorders which are characterized by presence of antinuclear antibodies (ANA) in the blood of patients.
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